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IBM tops the listing of vendors within the predictive analytics software house in accordance with a quadrant currently launched by means of 360Quadrants, followed intently by Oracle and SAP SE. IBM’s SPSS Modeler become rated the optimum in product high-quality, reliability, and breadth and depth of providing. IBM SPSS Modeler besides captured the excellent spot in standards fancy geographic footprint and viability of enterprise.
360Quadrants defines predictive analytics as a statistical and facts mining retort along with numerous algorithms and methodologies used for structured as well as unstructured data to extract enterprise insights.
360Quadrants covers 50+ products within the predictive analytics space and areas the remedy 31 of them in a quadrant reckoning on their great, reliability, and company outcomes. These 31 products are categorized into Visionary Leaders, Dynamic Differentiators, emerging agencies, and Innovators.
360Quadrants acknowledges IBM Corp, SAS Institute, Inc., SAP SE, reasonable Issac agency (FICO), Tableau software, Inc., RapidMiner, Inc., Oracle Corp, and Angoss utility Corp as Visionary Leaders; TIBCO software, Inc., Microstrategy, Inc., Alteryx, Inc., information Builder, Dataiku, KNIME.COM AG, and NTT information corporation, as Innovators; GoodData corporation, Microsoft corporation, Teradata trade enterprise, Sisense, Inc., Predixion software, and Domino records Lab, Inc. as Dynamic Differentiators; and Exago, incorporated, AgilOne, QlikTech international, and Kognitio Ltd. as rising players.
IBM's SPSS predictive analytics tools encompass IBM SPSS Modeler and IBM SPSS facts. SPSS Modeler offers records mining and textual content evaluation application, while SPSS data is an integrated family of products. both tools permit users to build predictive fashions and execute other analytics tasks.
The IBM SPSS Modeler goals clients who absorb shrimp or no programming abilities. clients are supplied with a drag-and-drop person interface, enabling them to build predictive fashions and operate other data analytics. Modeler can apply distinct procedures and algorithms to back the consumer determine assistance hidden in the records. The device can besides aid in integrating and consolidating every kindly of information sets from dispersed data sources throughout the organization.
The IBM SPSS statistics suite is an integrated set of products geared towards more skilled statistics analysts. SPSS records addresses the comprehensive analytical procedure, from planning to records collection, analysis, reporting and deployment.IBM SPSS Modeler points
edition 18 gives here features:
SPSS Modeler bundles are deployed on premises, and SPSS Modeler Gold is attainable as a cloud offering. The client front conclusion of SPSS Modeler runs under home windows and macOS, while the server constituent runs on Unix, Linux and home windows.
IBM SPSS Modeler provides the following editions:
SPSS data edition 24 includes the following current points:
IBM SPSS information presents here three variations (each and every with additional modules):
Pricing for the SPSS Modeler and SPSS data predictive analytics tools sweep counting on the bundle alternatives, the number of users and the license length. SPSS statistics is now available as a subscription choice or a perpetual license. IBM offers free trials of each IBM SPSS Modeler and IBM SPSS data.subsequent Steps
Why the time age unstructured facts is a misnomer
How huge information is altering information modeling ideas
massive facts programs pose current challenges to records governanceconnected substances View more
IBM Watson Studio is an incredibly powerful records science offering. in case you’re now not time-honored, Watson Studio is an built-in ambiance designed to sequel it convenient to advance, train, and manage fashions. It comprises a big choice of tools used for every thing from statistics prep and blend to image cognizance. And now Watson Studio is on its option to your windows or Mac desktop computing device.Overview of Watson Studio
Watson Studio includes a lot of tools outright within one built-in atmosphere. essentially the most frequent tools of Watson Studio are:
Watson Studio will soon breathe accessible as three deployment options:
Watson Studio computing device is their current 3rd deployment choice within the Watson Studio family. It takes essentially the most widespread parts of what is purchasable inside Watson Studio on the cloud and ports it to your windows or Mac computing device for offline use, for evaluation of records files you don’t necessity to add, and for snappy performance. outright with a speedy and simple laptop installation.
Watson Studio on the desktop will scale from an individual consumer outright the manner up to a big team, and should breathe an outstanding addition to the Watson Studio household along with their cloud and local flavors.
The initial main aspects of Watson Studio computer might breathe a SPSS Modeler canvas at the side of the statistics refinery spreadsheet editor. this could consist of backwards compatibility for SPSS Modeler streams.benefits of Watson Studio laptop
The Beta for Watson Studio is birth now with two tools already ported to the computing device: a refreshed version of SPSS Modeler & data Refinery. it's going to additionally encompass tasks to prepare your work, statistics property firm, and a simple examine for updates characteristic.
be Part of the beta to deliver remarks on how you fancy these equipment, and hint which different tackle they carry to the desktop. The Beta is a Part of the IBM SPSS Modeler Subscription Trial, so when you register for that you just’ll absorb entry to both downloads.
After you register, eye for the “IBM SPSS Modeler Subscription Trial” card, click on down load, then you’ll discern the Watson Studio computing device Beta downloads on the remedy hand facet of the page.join the discussion on the beta neighborhood
After registering for the beta, connect within the discussion on the Watson Studio desktop beta group. perquisite here that you would breathe able to put a question to questions about the beta, supply ideas for future features, come by forum assist, and retract Part in valuable surveys to influence product path. breathe Part of the forum perquisite here with the aid of logging in along with your IBMid.
stay up for future announcements perquisite here about this entertaining addition for the Watson Studio household.Watson Studio computer undertaking organizer
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IBM's SPSS predictive analytics tools consist of IBM SPSS Modeler and IBM SPSS Statistics. SPSS Modeler provides data mining and text analysis software, while SPSS Statistics is an integrated family of products. Both tools enable users to build predictive models and execute other analytics tasks.
The IBM SPSS Modeler targets users who absorb shrimp or no programming skills. Users are provided with a drag-and-drop user interface, enabling them to build predictive models and accomplish other data analytics. Modeler can apply different processes and algorithms to aid the user determine information hidden in the data. The tool can besides assist in integrating and consolidating outright types of data sets from dispersed data sources across the organization.
The IBM SPSS Statistics suite is an integrated set of products geared toward more professional data analysts. SPSS Statistics addresses the complete analytical process, from planning to data collection, analysis, reporting and deployment.IBM SPSS Modeler features
Version 18 provides the following features:
SPSS Modeler bundles are deployed on premises, and SPSS Modeler Gold is available as a cloud offering. The client front terminate of SPSS Modeler runs under Windows and macOS, while the server component runs on Unix, Linux and Windows.
IBM SPSS Modeler provides the following editions:
SPSS Statistics version 24 includes the following current features:
IBM SPSS Statistics offers the following three editions (each with additional modules):
Pricing for the SPSS Modeler and SPSS Statistics predictive analytics tools vary depending on the bundle options, the number of users and the license period. SPSS Statistics is now available as a subscription option or a perpetual license. IBM offers free trials of both IBM SPSS Modeler and IBM SPSS Statistics.Next Steps
Why the term unstructured data is a misnomer
How colossal data is changing data modeling techniques
Big data systems pose current challenges to data governanceRelated Resources View More
This study recruited schizophrenia patients with long-term administration of olanzapine, whom were diagnosed positive, negative and cognitive impairment or emotional syndrome, according to the PNASS factor scores. Inclusion criteria: (1) age 18–60 years old;(2) no infectious disease, no chronic cardiovascular, digestive tract, endocrine, immune system and respiratory diseases within two weeks before blood sampling; (3) no family history of diabetes and no major liver or kidney disease; no harmful habits, such as addiction and alcohol abuse; (4) nonpregnancy or lactation; (5) treatment with other temper stabilizers or other atypical antipsychotics (with olanzapine as the primary drug), but no antihypertensive drugs or typical antipsychotics; (6) informed consent; (7) patients treated mainly with olanzapine over 2 months and without hypoglycemic drugs. This clinical study was approved by the Tongji Medical College Ethics Committee of Huazhong University of Science and Technology (HUST).
We called clinical patients with long-term administration of olanzapine from different hospitals to conduct this study, which included measuring the carcass weight, fasting blood glucose, and insulin levels and calculating the insulin resistance index (HOMA-IR index). In this study, they mainly relied on experienced clinicians to determine the grouping of patients. In clinical practice, they assessed the patient’s metabolic status and insulin sensitivity based on changes in carcass weight and fasting blood glucose after long-term olanzapine treatment. Based on the HOMA-IR index values, the patients were divided into the OS group (the insulin resistance index has similar variations as the average levels in traditional subjects, data not shown) and the OR group (the insulin resistance index is significantly higher than that of the average levels in traditional subjects).
All experiments were performed according to the guidelines and regulations under HUST. The demographic and clinical details of the samples are provided in Table 1.
After overnight fasting, 10-ml blood samples were obtained from the patients and placed in a test tube that contained EDTAK2 anticoagulant. Following centrifugation at 3000 rpm for 10 min, the plasma was stored at −80 °C for later use.Animals, Drug Treatment and Examination of Inflammatory Factors
Adult female Balb/c mice and Sprague Dawley rats (purchased from Beijing Huafu Kang Biotechnology Co., Ltd., animal license number: SCXK (Beijing) 2014–0004) were group-housed and maintained in the SPF animal leeway of the Animal Experiment center of HUST with a 12-hour light/dark cycle. The animal exercise and procedures were in accordance with the HUST Animal Ethics Committee regulations and requirements. outright experiments were performed under HUST animal guidelines and regulations.
The confiscate amount of olanzapine (TCI, Japan) was dissolved with 0.1 M hydrochloric acid solution, with 1 M sodium hydroxide solution to adjust the pH to 6.0. Olanzapine was intraperitoneally injected with dose justification as described and discussed in Wu, et al.50. Briefly, the injection doses were 10 mg/kg, injection volume of 10 ml/kg, with 0.1 M hydrochloric acid as the control. One week after the rodent animals were adaptively fed, they were randomly divided into two groups: the olanzapine treatment group and the control group. The olanzapine and control solvent were orally administered at 8:30 a.m. to 9 a.m. daily for 8 weeks.
After 8 weeks of administration, the carcass weight, fasting blood glucose and insulin levels were measured, and the Homeostasis model assessment insulin resistance (HOMA-IR) was calculated as shown in Supplemental Table S2. HOMA-IR = fasting blood glucose (mmol/L) * fasting insulin (mU/L) /22.5. The oral glucose tolerance test (OGTT) was performed after the terminate of the administration, and the belt under the blood glucose curve was calculated. Orbital blood samples were obtained in heparin-added EP tubes, plasma was collected, and white adipose tissue was carefully separated. The prefrontal cortex of the rat brains from the OS and OR groups were dissected and immediately stored at −80 °C for later use.
Blood glucose was measured by a blood glucose detector. Insulin and inflammatory cytokines (TNF-α, IL-6, IL-8 and IL-1β) were measured using ELISA Kits (Neobioscience, China).Adipocyte Cell Line and Differentiation Process
3T3-L1 fibroblasts (Shanghai Meixuan Biotechnology Co., Ltd.) were cultured in DMEM medium (which contained 4 mM L-glutamine, 4.5 g/L glucose and 10% fetal bovine serum) in a 5% CO2 incubator. After 2 days of fusion, the cells were stimulated for beefy synthesis in DMEM medium that contained 25 mmol/L glucose, 0.5 mmol/L isobutylmethylxanthine, 1 mmol/L dexamethasone, 10 mg/ml insulin and 10% fetal bovine serum. After 3 days, the cells were changed using DMEM medium with 10 mg/ml insulin and 10% FBS. The medium was changed every 2 days during 10–14 day experiment, when 90–95% cells showed adipocyte phenotype.Olanzapine Treatment of Adipocytes
After 3T3-L1 adipocytes (or transfected cells) were incubated with serum-free, lofty glucose, DMEM medium and olanzapine at the indicated concentrations were applied for the indicated time, the samples were incubated with 100 nM insulin or blank control solution without insulin for 30 min, and the supernatants were collected. The GOD-POD kit (Nanjing Jiancheng Bioengineering Institute, China) was used to determine the glucose content in the supernatants. The initial glucose content in the medium was subtracted from the glucose content in the supernatant to obtain the glucose content absorbed by the cells. The control cells were incubated with solvent only.Examination of Influence on Adipocyte Growth
After the 3T3-L1 adipocytes were treated with olanzapine under the specified conditions, 10 µL CCK-8 solution was added, and the cells were incubated in an incubator at 37 °C for 2 h. The absorbance at 450 nm was measured using a microplate reader to reckon the sequel of olanzapine on cell growth.Gene Expression and Knock-down
IκBα siRNA and P50/p65 siRNA were synthesized by Shanghai Gemma (Ribobio, China). Briefly, prior to transfection, cells were harvested by trypsinization and collected, and the cell density was adjusted to 2 × 105/ml. Corresponding siRNAs were transfected into 3T3-L1 adipocytes using Lipofectamine rTM2000. The positive and vector siRNA were used to assess the transfection and knock-down efficiency. The levels of mRNA and protein expression of the target genes were detected after 48 hours.Western Blotting Analyses
All cell lysates were collected via low-speed centrifugation. Briefly, cells were incubated ice-cooled lysis buffer for 30 minutes, vortexed and extracted the protein via centrifugation; the protein concentration was determined using the BCA method. SDS-PAGE electrophoresis and western blotting procedures were performed. Inflammation activates serine but not threonine phosphorylation of the insulin receptor substrate (IRS-1). Thus, the specific rabbit anti serine p-IRS1 antibody was purchased and applied in the present study, Cat:#2385, CST, USA, 1:500; the other corresponding protein primary antibodies used in this study were as follows: p65, (Cat:#8242, CST, USA, 1:2000); IκBα, (Cat:ab32518, Abcam, England, 1:2000); GLUT4, (Cat:ab33780, Abcam, England, 1:1000); p-AKT, (Cat:#4060, CST, USA, 1:2000); and GAPDH, (Cat:ab37168, Abcam, England, 1:10000). outright primary antibodies were raised from rabbits; thus, a secondary antibody (HRP-Goat anti Rabbit, Cat:AS1107, ASPEN, USA, 1:10000) was used for each western blot analysis. Gel imager detection was performed with an X-ray film reader (Kodak, Japan). A cell membrane GLUT4 assay using a membrane protein extraction kit was used to determine the GLUT4 protein expression.Quantitative Real-Time PCR
Approximately 100 mg of mouse adipose tissue was obtained and extracted by Trizol extraction (15596–026, Invitrogen™). The extracted RNA was added to the invert transcription reaction system for invert transcription. The primers for TNF-α were 5′-TCCCCAAAGGGATGAGAAGTT-3′ and 5′-GAGGAGGTTGACTTTCTCCTGG-3′. The primers for IL-6 were 5′-CTGGGAAATCGTGGAAATGAG-3′ and 5′-AAGGACTCTGGCTTTGTCTTTCT-3′. The primers for IL-1β were 5′-GGGCCTCAAAGGAAAGAATCT-3′ and 5′-GAGGTGCTGATGTACCAGTTGG-3′. The primers for IL-8 were 5′-GGCCCAATTACTAACAGGTTCC-3′ and 5′-TGACTTCACTGGAGTCCCGTAG-3′. The primers for GAPDH were 5′-TGAAGGGTGGAGCCAAAAG-3′ and 5′-AGTCTTCTGGGTGGCAGTGAT-3′. Real-time PCR was performed on a StepOne™ Real-Time PCR instrument using the SYBR® Premix Ex Taq™ kit (RR047A, TaKaRa, Japan). The calculation formula was as follows: ΔCt = Ct value of the target gene - Ct value of the reference gene; ΔΔCt = ΔCt of control group - ΔCt of the experimental group; the relative expression value of the target gene in the sample of the experimental group is 2ΔΔCt.Electrophoretic Mobility Shift Assay
Following the cell intervention experiment, the nucleoprotein was extracted, and the protein concentration was determined with the purchased kit. Gel was prepared. After the gel was completely solidified, it was electrophoresed for 1 h at 100 v. After the pre-electrophoresis was completed, the precooled electrophoresis buffer was replaced, and 5 µl of 5x sample buffer was added to the sample mixture. Electrophoresis was then immediately performed at 150 v for 30–45 minutes. The positively charged nylon membrane was placed in a 0.5 x TBE for 10 minutes. After the electrophoresis was completed, the entire shroud of the sample was removed and transferred. After the membrane was completed, the membrane was marked and cross-linked under UV for 10 min. The membrane was blocked with blocking solution for 15 minutes. After being diluted 300-fold with blocking solution, the antibody was fully reacted with the membrane for 15 minutes. The membrane was subsequently washed and balanced. The image to the protein side of the membrane was taken. The film was scanned and analyzed with the AlphaEaseFC system. The oligos were AGTTGAGGGGACTTTCCCAGGC(5′−3′) and TCAACTCCCCTGAAAGGGTCCG(5′−3′).Statistical Analyses
The PANSS scaling was used to measure the symptom severity of the patients with schizophrenia. The minimum scores for the positive, negative and general scales are 7, 7, and 16 and are used for the matched controls. Student’s t test was used to compare two groups for continuous variables. A Chi-square test was used to compare two groups for binary variables.
SPSS19.0 (SPSS Inc., IBM, USA) was used to process outright animal and cell experimental data as mean ± SD. Analysis of variance (ANOVA) was used to compare multiple groups, and the least significant inequity (LSD) was used for comparisons among groups. A logistic regression model was used for variables of each inflammatory factor with covariates of the HOMA-IR index. Pearson correlation scores were calculated for every inflammatory factor and the normalized HOMA-IR index values.
Statistical significance was set at p < 0.05. outright experiments were repeated at least 3 times.Ethical approval and informed consent
The exercise of outright human samples and blood tissues in this study complied with the guidelines and regulations of the Tongji Medical College Ethics Committee of Huazhong University of Science and Technology (HUST). outright experiments on human samples were approved by the Tongji Medical College Ethics Committee of HUST.
All experiments on rodents were approved by the HUST Animal Ethics Committee and were performed under the HUST animal guidelines and regulations.
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Cognos [19 Certification Exam(s) ]
College-Board [2 Certification Exam(s) ]
CompTIA [76 Certification Exam(s) ]
ComputerAssociates [6 Certification Exam(s) ]
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CSP [1 Certification Exam(s) ]
CWNA [1 Certification Exam(s) ]
CWNP [13 Certification Exam(s) ]
Dassault [2 Certification Exam(s) ]
DELL [9 Certification Exam(s) ]
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DRI [1 Certification Exam(s) ]
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ECDL [1 Certification Exam(s) ]
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ESPA [1 Certification Exam(s) ]
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Exin [40 Certification Exam(s) ]
ExtremeNetworks [3 Certification Exam(s) ]
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FCTC [2 Certification Exam(s) ]
Filemaker [9 Certification Exam(s) ]
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Fortinet [13 Certification Exam(s) ]
Foundry [6 Certification Exam(s) ]
FSMTB [1 Certification Exam(s) ]
Fujitsu [2 Certification Exam(s) ]
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GIAC [15 Certification Exam(s) ]
Google [4 Certification Exam(s) ]
GuidanceSoftware [2 Certification Exam(s) ]
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HDI [9 Certification Exam(s) ]
Healthcare [3 Certification Exam(s) ]
HIPAA [2 Certification Exam(s) ]
Hitachi [30 Certification Exam(s) ]
Hortonworks [4 Certification Exam(s) ]
Hospitality [2 Certification Exam(s) ]
HP [750 Certification Exam(s) ]
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Huawei [21 Certification Exam(s) ]
Hyperion [10 Certification Exam(s) ]
IAAP [1 Certification Exam(s) ]
IAHCSMM [1 Certification Exam(s) ]
IBM [1532 Certification Exam(s) ]
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ICAI [1 Certification Exam(s) ]
ICDL [6 Certification Exam(s) ]
IEEE [1 Certification Exam(s) ]
IELTS [1 Certification Exam(s) ]
IFPUG [1 Certification Exam(s) ]
IIA [3 Certification Exam(s) ]
IIBA [2 Certification Exam(s) ]
IISFA [1 Certification Exam(s) ]
Intel [2 Certification Exam(s) ]
IQN [1 Certification Exam(s) ]
IRS [1 Certification Exam(s) ]
ISA [1 Certification Exam(s) ]
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Isilon [4 Certification Exam(s) ]
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ITEC [1 Certification Exam(s) ]
Juniper [64 Certification Exam(s) ]
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Liferay [1 Certification Exam(s) ]
Logical-Operations [1 Certification Exam(s) ]
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LSI [3 Certification Exam(s) ]
Magento [3 Certification Exam(s) ]
Maintenance [2 Certification Exam(s) ]
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McData [3 Certification Exam(s) ]
Medical [69 Certification Exam(s) ]
Microsoft [374 Certification Exam(s) ]
Mile2 [3 Certification Exam(s) ]
Military [1 Certification Exam(s) ]
Misc [1 Certification Exam(s) ]
Motorola [7 Certification Exam(s) ]
mySQL [4 Certification Exam(s) ]
NBSTSA [1 Certification Exam(s) ]
NCEES [2 Certification Exam(s) ]
NCIDQ [1 Certification Exam(s) ]
NCLEX [2 Certification Exam(s) ]
Network-General [12 Certification Exam(s) ]
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NI [1 Certification Exam(s) ]
NIELIT [1 Certification Exam(s) ]
Nokia [6 Certification Exam(s) ]
Nortel [130 Certification Exam(s) ]
Novell [37 Certification Exam(s) ]
OMG [10 Certification Exam(s) ]
Oracle [279 Certification Exam(s) ]
P&C [2 Certification Exam(s) ]
Palo-Alto [4 Certification Exam(s) ]
PARCC [1 Certification Exam(s) ]
PayPal [1 Certification Exam(s) ]
Pegasystems [12 Certification Exam(s) ]
PEOPLECERT [4 Certification Exam(s) ]
PMI [15 Certification Exam(s) ]
Polycom [2 Certification Exam(s) ]
PostgreSQL-CE [1 Certification Exam(s) ]
Prince2 [6 Certification Exam(s) ]
PRMIA [1 Certification Exam(s) ]
PsychCorp [1 Certification Exam(s) ]
PTCB [2 Certification Exam(s) ]
QAI [1 Certification Exam(s) ]
QlikView [1 Certification Exam(s) ]
Quality-Assurance [7 Certification Exam(s) ]
RACC [1 Certification Exam(s) ]
Real-Estate [1 Certification Exam(s) ]
RedHat [8 Certification Exam(s) ]
RES [5 Certification Exam(s) ]
Riverbed [8 Certification Exam(s) ]
RSA [15 Certification Exam(s) ]
Sair [8 Certification Exam(s) ]
Salesforce [5 Certification Exam(s) ]
SANS [1 Certification Exam(s) ]
SAP [98 Certification Exam(s) ]
SASInstitute [15 Certification Exam(s) ]
SAT [1 Certification Exam(s) ]
SCO [10 Certification Exam(s) ]
SCP [6 Certification Exam(s) ]
SDI [3 Certification Exam(s) ]
See-Beyond [1 Certification Exam(s) ]
Siemens [1 Certification Exam(s) ]
Snia [7 Certification Exam(s) ]
SOA [15 Certification Exam(s) ]
Social-Work-Board [4 Certification Exam(s) ]
SpringSource [1 Certification Exam(s) ]
SUN [63 Certification Exam(s) ]
SUSE [1 Certification Exam(s) ]
Sybase [17 Certification Exam(s) ]
Symantec [134 Certification Exam(s) ]
Teacher-Certification [4 Certification Exam(s) ]
The-Open-Group [8 Certification Exam(s) ]
TIA [3 Certification Exam(s) ]
Tibco [18 Certification Exam(s) ]
Trainers [3 Certification Exam(s) ]
Trend [1 Certification Exam(s) ]
TruSecure [1 Certification Exam(s) ]
USMLE [1 Certification Exam(s) ]
VCE [6 Certification Exam(s) ]
Veeam [2 Certification Exam(s) ]
Veritas [33 Certification Exam(s) ]
Vmware [58 Certification Exam(s) ]
Wonderlic [2 Certification Exam(s) ]
Worldatwork [2 Certification Exam(s) ]
XML-Master [3 Certification Exam(s) ]
Zend [6 Certification Exam(s) ]
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